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| (R)-MG132 Basic information |
| Product Name: | (R)-MG132 | | Synonyms: | (R)-MG132;Cbz-L-leu-D-leu-L-leu-H;N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide;MG-132(R);benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;MG-132(S,R,S);(S,R,S)-(-)-MG-132;Z-Leu-D-leu-leu-al | | CAS: | 1211877-36-9 | | MF: | C26H41N3O5 | | MW: | 475.62 | | EINECS: | | Product Categories: | peptides | | Mol File: | 1211877-36-9.mol |
| (R)-MG132 Chemical Properties |
| storage temp. | -20°C | | form | powder |
| (R)-MG132 Usage And Synthesis |
| Description | The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 μM (ChTL); 34.4 versus 104.43 μM (TL); 2.95 versus 5.70 μM (PGPH), respectively). | | Uses | (R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor. | | Uses | (R)-MG-132 is a potent, reversible and selective tripeptide aldehyde proteasome inhibitor. | | Biochem/physiol Actions | MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132. |
| (R)-MG132 Preparation Products And Raw materials |
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