Other grades of this product :
| Valspodar Basic information |
| Product Name: | Valspodar | | Synonyms: | Valspodar;3'-Keto-bmt(1)-Val(2)-cyclosporin a;Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-;Psc 833;Sdz psc 833;Sdz-psc-833;Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl];6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA | | CAS: | 121584-18-7 | | MF: | C63H111N11O12 | | MW: | 1214.62 | | EINECS: | 1312995-182-4 | | Product Categories: | Intermediates & Fine Chemicals;Peptides;Pharmaceuticals | | Mol File: | 121584-18-7.mol |
| Valspodar Chemical Properties |
| Melting point | 143-145°C | | Boiling point | 1290.1±65.0 °C(Predicted) | | alpha | D20 -255.1° (c = 0.5 in CHCl3) | | density | 1.015±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 12.45±0.70(Predicted) | | form | powder | | color | white to beige |
| Valspodar Usage And Synthesis |
| Description | PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain. | | Chemical Properties | White Solid | | Uses | Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor. | | Uses | Antineoplastic adjunct (chemosensitizer). | | Brand name | Amdray (Novartis). | | Biochem/physiol Actions | Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein. |
| Valspodar Preparation Products And Raw materials |
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