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| Amiodarone-D4 HCl Basic information |
| Product Name: | Amiodarone-D4 HCl | | Synonyms: | Amiodarone-D4 hydrochloride solution;(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);[2H4]-Amiodarone Hydrochloride;Amiodarone hydrochloride salt;Amiodarone D4 HydrochlorideQ: What is
Amiodarone D4 Hydrochloride Q: What is the CAS Number of
Amiodarone D4 Hydrochloride Q: What is the storage condition of
Amiodarone D4 Hydrochloride Q: What are the applications of
Amiodarone D4 Hydrochloride | | CAS: | 1216715-80-8 | | MF: | C25H30ClI2NO3 | | MW: | 681.78 | | EINECS: | 806-400-9 | | Product Categories: | | Mol File: | 1216715-80-8.mol |
| Amiodarone-D4 HCl Chemical Properties |
| Amiodarone-D4 HCl Usage And Synthesis |
| Description | Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations. | | General Description | A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range. |
| Amiodarone-D4 HCl Preparation Products And Raw materials |
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