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| PROTRIPTYLINE HYDROCHLORIDE Basic information |
| PROTRIPTYLINE HYDROCHLORIDE Chemical Properties |
| Melting point | 169-171° | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | H2O: soluble50mg/mL | | pka | 8.2(at 25℃) | | form | powder | | color | white to off-white |
| PROTRIPTYLINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Monoamine reuptake inhibitor; tricyclic antidepressant. | | Brand name | Vivactil (Odyssey). | | General Description | Protriptyline hydrochloride, N-methyl-5H-dibenzo[a,d]-cycloheptene-5-propylamine hydrochloride, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene hydrochloride(Vivactil), like the other compounds under consideration, isan effective antidepressant. The basis for its chemical namingcan be seen by consulting the naming and the structureof imipramine. Protriptyline is a structural isomer of nortriptyline.Inactivation can be expected to involve the relativelylocalized double bond. Because it is a monomethylcompound, its sedative potential is low. | | Biochem/physiol Actions | Norepinephrine uptake blocker. |
| PROTRIPTYLINE HYDROCHLORIDE Preparation Products And Raw materials |
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