| CGP 35348 Basic information |
| Product Name: | CGP 35348 |
| Synonyms: | CGP 35348;(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID;(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate;CGP 35348 hydrate;P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid;Phosphinic acid, (3-aminopropyl)(diethoxymethyl)- |
| CAS: | 123690-79-9 |
| MF: | C8H20NO4P |
| MW: | 225.22 |
| EINECS: | |
| Product Categories: | GABA/Glycine receptor;GABA |
| Mol File: | 123690-79-9.mol |
| CGP 35348 Chemical Properties |
| storage temp. | −20°C |
| solubility | H2O: >10 mg/mL |
| form | solid |
| color | white |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| CGP 35348 Usage And Synthesis |
| Uses | CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
|
| Biological Activity | Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors. |
| Biochem/physiol Actions | CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier. |
| references | [1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93. |
| CGP 35348 Preparation Products And Raw materials |
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