Other grades of this product :
| A971432 Basic information |
| Product Name: | A971432 | | Synonyms: | A971432;1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid;1-(4-((3,4-dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid;A-971432 >=95% (HPLC) | | CAS: | 1240308-45-5 | | MF: | C18H17Cl2NO3 | | MW: | 366.24 | | EINECS: | 827-461-8 | | Product Categories: | | Mol File: | 1240308-45-5.mol |
| A971432 Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white to beige |
| A971432 Usage And Synthesis |
| Uses | A 971432 is used in the preparation of benzylazetidinecarboxylate derivatives as agonists and antagonists of the S1P5 receptor. | | Biochem/physiol Actions | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50?= 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50?>10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t1/2??= 5.7 h; Cmax?= 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg. |
| A971432 Preparation Products And Raw materials |
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