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| N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine Basic information |
| N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine Chemical Properties |
| N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine Usage And Synthesis |
| General Description | Ceramides linked to 2-hydroxy fatty acids (hFA) are present in the surface epithelium of the skin. 20:0(2S-OH) Ceramide is a unique ceramide containing 20C long chain base fatty acid (arachidic acid)-with 2′-hydroxyl group in S configuration. | | Biochem/physiol Actions | Hydroxy fatty acid (hFA)-sphingolipids help in formation and function of myelin. In addition, they also play a vital role in cell signaling, cell differentiation and apoptosis. In epidermis, hFA-ceramides aid in permeability barrier function. NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramides. FA2H gene mutation leads to the development of neurological disorders such as leukodystrophy and spastic paraparesis in humans. hFA-ceramides help PM02734 (elisidepsin), an?antitumor drug to exhibit its activity. |
| N-(2'-(S)-hydroxyarachidoyl)-D-erythro-sphingosine Preparation Products And Raw materials |
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