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| Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Basic information |
| Product Name: | Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) | | Synonyms: | Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt);O-3-Deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-4)-O-3-deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1-6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] ammonium salt (1:4);DI[3-DEOXY-D-MANNO-OCTULOSONYL]-LIPID A (AMMONIUM SALT);KDO2-LIPID A;Kdo2-Lipid A;Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution;Kdo2-Lipid A (KLA);Kdo2-Lipid A ammonium | | CAS: | 1246298-62-3 | | MF: | C110H214N6O39P2 | | MW: | 2306.840482 | | EINECS: | | Product Categories: | | Mol File: | 1246298-62-3.mol |
| Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Chemical Properties |
| storage temp. | -20°C | | form | solid |
| Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Usage And Synthesis |
| Uses | Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice. | | Uses | Kdo2-Lipid A (KLA) has been used:- as a toll like receptor (TLR) ligand source in immortalized murine macrophage culture media
- in 2H-,13C-,15N-labeled OprHΔL1ΔL4 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) micelles, to determine the specific residues of OprHΔL1ΔL4 interacting with lipopolysaccharides (LPS) source
- as a component of LPS stock to study its role in lipopolysaccharide induced prion protein conversion
| | General Description | 3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model. | | Biochem/physiol Actions | Kdo2-Lipid A might be useful to stimulate inflammatory response. |
| Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Preparation Products And Raw materials |
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![Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)](/img/1246298-62-3.jpg "Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)")
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