Other grades of this product :
| C6 CERAMIDE Basic information |
| Product Name: | C6 CERAMIDE | | Synonyms: | N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxyMethyl)-3-heptadecen-1-yl]hexanaMide;C6 Ceramide (d18:1/6:0);N-HEXANOYL-D-ERYTHRO-SPHINGOSINE;C6 CERAMIDE (D18:1/6:0);6-Hexanoyl-D-erythro-sphingosine, 99+%;C6 ceramide, Caproyl ceramide, N-Caproyl-D-sphingosine;6-HEXANOYL-D-ERYTHRO-SPHINGOSINE, SYNTHETICAL, 99+%;6-Hexanoyl-D-erythro-sphingosine, synthetical;6-Hexanoyl-D-erythro-sphingosine,99+%,synthetical | | CAS: | 124753-97-5 | | MF: | C24H47NO3 | | MW: | 397.63 | | EINECS: | | Product Categories: | Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators | | Mol File: | 124753-97-5.mol |
| C6 CERAMIDE Chemical Properties |
| Melting point | 76-77°C | | Boiling point | 521.03°C (rough estimate) | | density | 1.0077 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | -20°C | | solubility | Soluble in 100% ethanol at 25mg/ml and also in DMSO at 50mg/ml. | | pka | 13.53±0.20(Predicted) | | form | Powder | | color | White | | Stability: | Freezer -20°C |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29241990 |
| C6 CERAMIDE Usage And Synthesis |
| Description | C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 ceramide acts in neuronal axons to inhibit neurite growth. | | Chemical Properties | Off White Powder | | Uses | A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway. | | Uses | C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells. | | General Description | Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells. | | Biochem/physiol Actions | C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis. When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines. C6 Ceramide may serve as an adjunct in chemotherapy. It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation. |
| C6 CERAMIDE Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye