| RO-31-7549 Basic information |
| Product Name: | RO-31-7549 |
| Synonyms: | BISINDOLYLMALEIMIDE VIII ACETATE;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;Bisindolylmaleimide VIII;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;RO-31-7549;RO 31-7549 ACETATE SALT;BIDINDOLYLMALEIMIDE VIII, ACETETE |
| CAS: | 125313-65-7 |
| MF: | C24H22N4O2 |
| MW: | 398.46 |
| EINECS: | |
| Product Categories: | Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators |
| Mol File: | 125313-65-7.mol |
| RO-31-7549 Chemical Properties |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| form | Red to reddish-orange solid |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| RO-31-7549 Usage And Synthesis |
| Uses | It is a potent inhibitor of protein kinase C (PKC) activity. |
| General Description | A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM). |
| Biochem/physiol Actions | Cell permeable: yes |
| RO-31-7549 Preparation Products And Raw materials |
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