Other grades of this product :
| Product Name: | CD437 | | Synonyms: | 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen;6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic;AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;O-DesMethyl Adapalene;CD 437/AHPN;Adapalene IMpurity F;Apoptosis Activator VI, CD437/AHPN;ADAP-IME | | CAS: | 125316-60-1 | | MF: | C27H26O3 | | MW: | 398.49 | | EINECS: | 200-258-5 | | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 125316-60-1.mol |
| CD437 Chemical Properties |
| Melting point | 271.6-276 °C | | Boiling point | 595.0±50.0 °C(Predicted) | | density | 1.290 | | storage temp. | -20°C | | solubility | DMSO: 26 mg/mL | | form | solid | | pka | 4.17±0.30(Predicted) | | color | yellow |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | QJ1975900 |
| CD437 Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | An intermediate in the preparation of Adapalene derivatives. | | Definition | ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g
mma and induces cell cycle arrest and apoptosis in various cancer cells. | | Biological Activity | Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis. | | Biochem/physiol Actions | CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis. |
| CD437 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye