Eltanolone

CAS No.：128-20-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Eltanolone Basic information

Product Name:	Eltanolone
Synonyms:	3alpha,5beta-Epimeric pregnanolone;3alpha,5beta-Pregnanolone;3-alpha-hydroxy-5-beta-pregnan-20-on;Pregnan-20-one, 3-hydroxy-, (3a,5b)-;Pregnan-3α-ol-20-one;3a,5b-Epimeric pregnanolone;1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone;5B-Pregnan-3α-ol-20-one
CAS:	128-20-1
MF:	C21H34O2
MW:	318.49
EINECS:
Product Categories:	Steroids;Pharmaceutical Intermediates
Mol File:	128-20-1.mol

Eltanolone Chemical Properties

Melting point	149°C
alpha	D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol)
Boiling point	397.64°C (rough estimate)
density	1.0234 (rough estimate)
refractive index	1.5344 (estimate)
storage temp.	Store at RT
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	15.12±0.70(Predicted)
form	Solid
color	White to Off-White
Water Solubility	8mg/L(room temperature)
NIST Chemistry Reference	3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1)

Safety Information

Hazard Codes	Xn
Risk Statements	40
Safety Statements	22-36
WGK Germany	3
RTECS	TU4384000
Toxicity	LD50 in mice, rats (mg/kg): 66 ± 10, 27.5 ± 2.4 i.v. (Gyermek)

MSDS Information

Provider	Language
Eltanolone	English

Eltanolone Usage And Synthesis

Uses	A hyponotic-anaesthetic agent
Uses	A hyponotic-anaesthetic agent.
Definition	ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.
Biological Activity	GABA A receptor positive allosteric modulator. Neuroactive steroid.
Biochem/physiol Actions	5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.

Eltanolone Preparation Products And Raw materials

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