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| Product Name: | DPQ | | Synonyms: | PARP Inhibitor III, DPQ;5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one;DPQ;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE;3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE;3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE;5-[4-(1-PIPERIDINYL)-BUTYLOXY]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE | | CAS: | 129075-73-6 | | MF: | C18H26N2O2 | | MW: | 302.41 | | EINECS: | | Product Categories: | | Mol File: | 129075-73-6.mol |
| Melting point | 107-109° | | Boiling point | 528.8±50.0 °C(Predicted) | | density | 1.096±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | solid | | pka | 14.54±0.20(Predicted) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| Description | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals. | | Uses | 3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons
e to reactive oxygen and nitrogen species. | | Uses | Reagent for inhibition of PARP. | | Uses | DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation. | | Biochem/physiol Actions | 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide. |
| DPQ Preparation Products And Raw materials |
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