Other grades of this product :
| Product Name: | Ogerin | | Synonyms: | Ogerin;2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol;Benzenemethanol, 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-;Ogerin >=98% (HPLC) | | CAS: | 1309198-71-7 | | MF: | C17H17N5O | | MW: | 307.35 | | EINECS: | | Product Categories: | | Mol File: | 1309198-71-7.mol |
| Ogerin Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white to beige |
| Ogerin Usage And Synthesis |
| Uses | Ogerin is a potent GPR68 modulator. | | Biochem/physiol Actions | Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory. | | Enzyme inhibitor | This GPR68 activator (FW = 307.35 g/mol; CAS 1309198-71-7), also named 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol, selectively and allosterically targets G-Protein-coupled Receptor 68, one of at least 120 non-olfactory G-protein-coupled receptors in the human genome that remain 'orphans' (i.e., they are pharmacologically dark, with no known endogenous ligands). Ogerin suppresses recall in fear conditioning in wild-type, but not in GPR68-knockout mice. GPR68 is also a newly recognized metastasis suppressor gene in certain cancers. |
| Ogerin Preparation Products And Raw materials |
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