Other grades of this product :
| Ro 25-6981 (Maleate) Basic information |
| Product Name: | Ro 25-6981 (Maleate) | | Synonyms: | [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt;1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1) | | CAS: | 1312991-76-6 | | MF: | C26H33NO6 | | MW: | 455.543 | | EINECS: | | Product Categories: | API | | Mol File: | 1312991-76-6.mol |
| Ro 25-6981 (Maleate) Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble2mg/mL (clear solution, warmed) | | form | powder | | color | white to beige | | optical activity | [α]/D +15 to +22°, c = 1 in methanol |
| Hazard Codes | Xi,N | | Risk Statements | 36/37/38-50 | | Safety Statements | 26-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| Ro 25-6981 (Maleate) Usage And Synthesis |
| Uses | Ro 25-6981 maleate is a potent NMDA receptor antagonist. | | Biochem/physiol Actions | Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models. |
| Ro 25-6981 (Maleate) Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye