Other grades of this product :
| AZD2461 Basic information |
| Product Name: | AZD2461 | | Synonyms: | 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one;4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone;CS-739;AZD2461;4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one;1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-;AZD 2461, >=98%;AZD2461 USP/EP/BP | | CAS: | 1174043-16-3 | | MF: | C22H22FN3O3 | | MW: | 395.43 | | EINECS: | | Product Categories: | Inhibitors;Inhibitor | | Mol File: | 1174043-16-3.mol |
| AZD2461 Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥45.2 mg/mL in EtOH with ultrasonic | | form | powder | | pka | 12.07±0.40(Predicted) | | color | white to beige |
| AZD2461 Usage And Synthesis |
| Uses | 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor. | | Biochem/physiol Actions | AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein. |
| AZD2461 Preparation Products And Raw materials |
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