2-Hydroxybenzophenone

CAS No.：117-99-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Hydroxybenzophenone Basic information

Product Name:	2-Hydroxybenzophenone
Synonyms:	(2-Hydroxy-phenyl)-phenylmethanon;2-Hydroxybenzophenone99%;2-HYDROXYBENZOPHENONE 99%;2-Hydroxybenzophenone, 99% 1GR;2-Hydroxybenzophenone, 99% 25GR;(2-hydroxyphenyl)phenyl-methanon;(2-hydroxyphenyl)phenylmethanone;(2-Hydroxy-phenyl)-phenylmethanone
CAS:	117-99-7
MF:	C13H10O2
MW:	198.22
EINECS:	204-226-2
Product Categories:	Aromatic Benzophenones & Derivatives (substituted);API intermediates;Linkers for Solid Phase Synthesis;C13 to C14;Carbonyl Compounds;Ketones
Mol File:	117-99-7.mol

2-Hydroxybenzophenone Chemical Properties

Melting point	37-39 °C (lit.)
Boiling point	171-173 °C/12 mmHg (lit.)
density	1.1184 (rough estimate)
refractive index	1.5954 (estimate)
Fp	>230 °F
storage temp.	Sealed in dry,2-8°C
pka	8.07±0.30(Predicted)
form	Crystalline Powder
color	Yellow
Water Solubility	insoluble
BRN	1638174
CAS DataBase Reference	117-99-7(CAS DataBase Reference)
NIST Chemistry Reference	Methanone, (2-hydroxyphenyl)phenyl-(117-99-7)
EPA Substance Registry System	Methanone, (2-hydroxyphenyl)phenyl- (117-99-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-36
WGK Germany	3
TSCA	Yes
HazardClass	IRRITANT
HS Code	29145000

MSDS Information

Provider	Language
2-Hydroxybenzophenone	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Hydroxybenzophenone Usage And Synthesis

Chemical Properties	yellow crystalline powder
Uses	UV absorber in plastics.
Uses	2-Hydroxybenzophenone was used to quantify the metabolites of unmethylated extracts from the supernatants of Pseudomonas acidovorans cultures grown on 1,1-diphenylethylene.
Application	2-Hydroxybenzophenone was used to quantify the metabolites of unmethylated extracts from the supernatants of Pseudomonas acidovorans cultures grown on 1,1-diphenylethylene.2-Hydroxybenzophenone forms copolymer 2-hydroxy, 3-allyl, 4,4′-dimethoxybenzophenone with methyl methacrylate.It forms photostabilizer compounds with 2,2,6,6-tetramethylpiperidine under phase transfer catalysis conditions.It reacts with 3-aminophenyl boronic acid to form macrocyclic boronates.
Preparation	Preparation by Friedel–Crafts acylation of benzene in the presence of aluminium chloride, ? with 2-hydroxybenzoyl chloride (salicylic acid chloride), (52%), (39%), at temperature <60°; ? with o-anisoyl chloride. Demethylation occurred during the Friedel–Crafts acylation, especially in the presence of ferric chloride at 130–140°; ? with 2-ethoxybenzoyl chloride in a boiling water bath (42%).
Synthesis Reference(s)	Journal of the American Chemical Society, 76, p. 5469, 1954 DOI: 10.1021/ja01650a062The Journal of Organic Chemistry, 32, p. 3844, 1967 DOI: 10.1021/jo01287a027
General Description	2-Hydroxybenzophenone forms copolymer 2-hydroxy, 3-allyl, 4,4′-dimethoxybenzophenone with methyl methacrylate. It forms photostabilizer compounds with 2,2,6,6-tetramethylpiperidine under phase transfer catalysis conditions. It reacts with 3-aminophenyl boronic acid to form macrocyclic boronates.

2-Hydroxybenzophenone Preparation Products And Raw materials

Raw materials	4-Hydroxybenzophenone-->2-[hydroxy(phenyl)methyl]phenol-->2(3H)-Benzofuranone,3-phenyl--->2-IODOBENZOPHENONE-->2-(ACETYLOXY)-BENZALDEHYDE-->3-HYDROXYBENZOPHENONE-->CHROMONE-3-CARBOXALDEHYDE-->Phenylboronic acid-->Phenol-->Crotonaldehyde-->Iodobenzene-->2-Iodophenol-->2-Methylbenzyl alcohol
Preparation Products	2-Hydroxydiphenylmethane

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