Other grades of this product :
| STEM CELL FACTOR, HUMAN Basic information |
| Product Name: | STEM CELL FACTOR, HUMAN | | Synonyms: | RHSCF;RECOMBINANT HUMAN SCF;REC STEM CELL FACTOR (HUMAN);REC SCF (HUMAN);SCF, HUMAN;STEM CELL FACTOR, HUMAN;STEM CELL FACTOR, HUMAN, RECOMBINANT;STEM CELL FACTOR, HUMAN, RECOMBINANT, E COLI | | CAS: | 133352-98-4 | | MF: | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| STEM CELL FACTOR, HUMAN Chemical Properties |
| storage temp. | −20°C | | form | powder |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2937190000 |
| STEM CELL FACTOR, HUMAN Usage And Synthesis |
| General Description | The KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32. | | Biochem/physiol Actions | Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors. |
| STEM CELL FACTOR, HUMAN Preparation Products And Raw materials |
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