Other grades of this product :
| CID-49830258 Basic information |
| Product Name: | CID-49830258 | | Synonyms: | 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;CS-2775;ML240, >98%;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;CID-49830258;ML240;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)- | | CAS: | 1346527-98-7 | | MF: | C23H20N6O | | MW: | 396.44 | | EINECS: | | Product Categories: | API | | Mol File: | 1346527-98-7.mol |
| CID-49830258 Chemical Properties |
| Boiling point | 696.6±65.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | pka | 4.53±0.10(Predicted) | | form | powder | | color | , white to yellow to light brown |
| CID-49830258 Usage And Synthesis |
| Uses | ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases. | | Uses | ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein. | | Biochem/physiol Actions | ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines. |
| CID-49830258 Preparation Products And Raw materials |
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