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| SPERMINE NONOATE Basic information |
| Product Name: | SPERMINE NONOATE | | Synonyms: | (Z)-1-[N-[3-AMINOPROPYL]-N-[4-(3-AMINOPROPYL-AMMONIO)BUTYL]-AMINO]-DIAZEN-1-IUM-1,2-DIOLATE;(Z)-1-[N-(3-AMMONIOPROPYL)-N-[4-(3-AMINOPROPYLAMMONIO) BUTYL]-AMINO]DIAZEN-1-IUM-1,2-DIOLATE;SPERMINE BIS (NITRIC OXIDE) ADDUCT;SPERMINE/NITRIC OXIDE COMPLEX;SPERMINE NONOATE;SPER/NO;NOC-22;N-[4-[1-(3-AMINOPROPYL)-2-HYDROXY-2-NITROSOHYDRAZINO]BUTYL]-1,3-PROPANEDIAMINE | | CAS: | 136587-13-8 | | MF: | C10H26N6O2 | | MW: | 262.35 | | EINECS: | | Product Categories: | Nitric Oxide Reagents;Amines | | Mol File: | 136587-13-8.mol |
| SPERMINE NONOATE Chemical Properties |
| Melting point | 105-107°C | | Boiling point | 405.6°C (rough estimate) | | density | 1.0879 (rough estimate) | | refractive index | 1.7000 (estimate) | | storage temp. | -20°C | | solubility | methanol: ≥1mg/mL | | form | White solid | | pka | 5.47±0.69(Predicted) | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use. |
| SPERMINE NONOATE Usage And Synthesis |
| Description | Spermine NONOate (136587-13-8) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner.? ? The half-life of Spermine NONOate in 0.1 M phosphate buffer at pH 7.4 is 39 min at 37 °C, or 230 min at room temperature.1? ? Dissociation is essentially instantaneous at a pH of 5.0. | | Chemical Properties | Off-White Solid | | Uses | A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies | | Uses | A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies. | | General Description | Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t?) of NO release = 230 min (PBS, pH 7.4, 22°C). | | Biological Activity | A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC 50 = 6.2 μ M for relaxation of rabbit aorta, and t=39 min at 37℃, pH 7.4, aqueous solution). | | Biochem/physiol Actions | Product does not compete with ATP. | | References | 1) Keefer et al. (1996), “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol., 268 281 |
| SPERMINE NONOATE Preparation Products And Raw materials |
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