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| Biotinylated isoxazole 95% Basic information |
| Product Name: | Biotinylated isoxazole 95% | | Synonyms: | Biotinylated isoxazole 95%;1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 6-[[[5-(2-thienyl)-3-isoxazolyl]carbonyl]amino]hexyl ester, (3aS,4S,6aR)-;Biotinylated isoxazole;Biotin isoxazole | | CAS: | 1377605-22-5 | | MF: | C24H32N4O5S2 | | MW: | 520.66 | | EINECS: | | Product Categories: | | Mol File: | 1377605-22-5.mol |
| Biotinylated isoxazole 95% Chemical Properties |
| Boiling point | 800.4±65.0 °C(Predicted) | | density | 1.251±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (30 mg/ml with warming) | | form | powder or crystals | | pka | 13.77±0.46(Predicted) | | color | Beige | | Stability: | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Biotinylated isoxazole 95% Usage And Synthesis |
| Description | Biotin-isoxazole (1377605-22-5) precipitates hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules.1,2 In one study roughly 580 nuclear proteins were identified as being precipitated by B-Isox including TAF15, RNA polymerase II (largest subunit), numerous subunits of the mediator complex as well as a variety of enzymes involved in epigenetic modification of histones.3? SR domains were found to be the determinant that facilitates B-Isox precipitation.4 Also allows for the fractionation / isolation of SG-associated proteins and RNA precipitates.5 | | Uses | When exposed to cells or tissue lysates, biotinylated isoxazole (b-isox) was shown to precipitate RNA-binding proteins with significant overlap to the components of RNA granules. By reversibly aggregating and disaggregating structures similar to RNA granules, b-isox has lent insight to polypeptides necessary for the reversible aggregation of RNA-binding proteins.This product was previously listed as T511617. | | References | Kato et al. (2012), Cell-free formation of rNA granules: low complexity sequence domains form dynamic fibers within hydrogels; Cell, 149 753
Han et al. (2012), Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies; Cell, 149 768
Kwon et al. (2013), Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains; Cell, 155 1049
Kwon et al. (2014), Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells; Science, 345 1139
Panas et al. (2015), Methods for the characterization of stress granules in virus infected cells; Methods, 90 57 |
| Biotinylated isoxazole 95% Preparation Products And Raw materials |
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