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| (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Basic information |
| Product Name: | (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL | | Synonyms: | (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL;(2S,6S)-Hydroxynorketamine;(2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;2S,6S-Hydroxynorketamine hydrochloride;(2S,6S)-Hydroxynorketamine hydrochloride >=98% (HPLC);(2S,6S)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride | | CAS: | 1430202-70-2 | | MF: | C12H15Cl2NO2 | | MW: | 276.159 | | EINECS: | | Product Categories: | | Mol File: | 1430202-70-2.mol |
| (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white to beige | | optical activity | [α]/D +95 to +115°, c = 1 in H2O |
| (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Usage And Synthesis |
| Biochem/physiol Actions | (2S,6S)-Hydroxynorketamine hydrochlorideKetamine is a metabolite associated with increased locomotor activity and motor incoordination.It has been found that the NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects, while (2S,6S)-hydroxynorketamine was associated with increased locomotor activity and motor incoordination. (2S,6S)-HNK, was also found to increase the function of the mammalian target of rapamycin (mTOR) 2-fold at 0.05 nM. (2S,6S)-HNK and (2R,6R)-HNK both inhibited intracellular concentrations of D-serine, an endogenous NMDA receptor co-agonist, with IC50 values of 0.18 nM and 0.68 nM, respectively. Neither bind with high affinity to NMDA receptors, with Ki values of 21.19 μM and > 100 μM for (2S,6S)-HNK and (2R,6R)-HNK, respectively. |
| (2S,6S)-2-AMINO-2-(2-CHLOROPHENYL)-6-HYDROXYCYCLOHEXAN-1-ONE HCL Preparation Products And Raw materials |
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