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3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-

CAS No.：120964-45-6

Other grades of this product :

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Basic information

Product Name:	3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
Synonyms:	3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-;3-Deazaneplanocin A (hydrochloride);3-Deazaneplanocin hydrochloride;DZNep hydrochloride;DZNEP; NSC 617989;NSC 617989 hydrochloride;(-)-1-[(1R,4R,5S)-3-(HydroxyMethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aMinoiMidazo[4,5-c]pyridine hydrochloride DZNep hydrochloride;(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride (1:1)
CAS:	120964-45-6
MF:	C12H15ClN4O3
MW:	298.7255
EINECS:
Product Categories:	Inhibitors;1
Mol File:	120964-45-6.mol

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Chemical Properties

Melting point	168-169℃
storage temp.	-20°C
solubility	H2O: ≥5mg/mL
form	Tan solid
color	white to beige
InChIKey	UNSKMHKAFPRFTI-FDKLLANESA-N

Safety Information

Hazard Codes	Xn
Risk Statements	22
WGK Germany	3

MSDS Information

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Usage And Synthesis

Uses	3-Deazaneplanocin A is a a powerful inhibitor of S-adenosylhomocysteine hydrolase that has shown potent and selective in vitro and in vivo antiviral activities.
Uses	3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.
General Description	3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic?property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.
Biochem/physiol Actions	3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Preparation Products And Raw materials

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