Other grades of this product :
| MKT 077 Basic information |
| Product Name: | MKT 077 | | Synonyms: | MKT 077;FJ 776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;MKT077;MKT-077;FJ-776;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);MKT-077 >=98% (HPLC), powder;1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride;MKT-077, ≥98% (HPLC) | | CAS: | 147366-41-4 | | MF: | C21H22ClN3OS2 | | MW: | 432.00188 | | EINECS: | | Product Categories: | | Mol File: | 147366-41-4.mol |
| MKT 077 Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble10mg/mL, clear | | form | powder | | color | orange to red |
| WGK Germany | 3 | | RTECS | UU4023332 | | Toxicity | LD50 intraperitoneal in mouse: 50mg/kg |
| MKT 077 Usage And Synthesis |
| Description | MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53. | | Uses | MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance | | Biochem/physiol Actions | MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells. |
| MKT 077 Preparation Products And Raw materials |
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