Product

LEUPEPTIN TRIFLUOROACETATE SALT

CAS No.：147385-61-3

Other grades of this product :

LEUPEPTIN TRIFLUOROACETATE SALT Basic information

Product Name:	LEUPEPTIN TRIFLUOROACETATE SALT
Synonyms:	LEUPEPTIN TRIFLUOROACETATE SALT;ACETYL-LEU-LEU-ARG-AL TRIFLUOROACETATE SALT;LEUPEPTIN TRIFLUOROACETATE FROM*MICROBIA L SOURCE;leupeptintrifluoroacetatesalt90+%;Leupeptin trifluoroacetate salt,Acetyl-Leu-Leu-Arg-al trifluoroacetate salt;Leupeptin trifluoroacetate salt >=90% (HPLC), microbial;2-acetamido-N-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide,2,2,2-trifluoroaceticaci
CAS:	147385-61-3
MF:	C22H39F3N6O6
MW:	540.58
EINECS:
Product Categories:	A to C;alpha;Apoptosis Enzymes;Application Index;Calpain II;Calpain II Inhibitors;Cathepsin B;Cathepsin H;Cathepsin/Granzyme Inhibitors &Cell Signaling Enzymes;Coagulation Proteins and Reagents;D to K;Endoproteinase Lys-C;General Inhibitors;Kallikrein tissue;Aldehydes;and Substrates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Calpain;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Chymotrypsin;Core Bioreagents;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;L;Lys;Substrates;inhibitor
Mol File:	147385-61-3.mol

LEUPEPTIN TRIFLUOROACETATE SALT Chemical Properties

storage temp.	-20°C
solubility	H₂O: 10 mM Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20°C.

Safety Information

Safety Statements	22-24/25
WGK Germany	3
HS Code	2925290090

MSDS Information

Provider	Language
SigmaAldrich	English

LEUPEPTIN TRIFLUOROACETATE SALT Usage And Synthesis

Uses

Leupeptin Trifluoroacetate is a protease inhibitor, used in the characterization of macroautophagic flux in vivo using leupeptin-based assay.

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

LEUPEPTIN TRIFLUOROACETATE SALT Preparation Products And Raw materials

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