Other grades of this product :
| thioperamide maleate salt Basic information |
| Product Name: | thioperamide maleate salt | | Synonyms: | MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1);MR-12842 maleate | | CAS: | 148440-81-7 | | MF: | C15H24N4SC4H4O4 | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | 148440-81-7.mol |
| thioperamide maleate salt Chemical Properties |
| storage temp. | desiccated
under inert gas | | solubility | H2O: >10mg/mL | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| thioperamide maleate salt Usage And Synthesis |
| Description | Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid. | | Uses | Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue. | | Biochem/physiol Actions | Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine. |
| thioperamide maleate salt Preparation Products And Raw materials |
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