Other grades of this product :
| BPV(PIC) Basic information |
| Product Name: | BPV(PIC) | | Synonyms: | DIPOTASSIUM BISPEROXO(PICOLINATO)OXOVANADATE (V);BPV(PIC);Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate;Dipotassium Bisperoxovanadium(pic) dihydrate;K2 [VO(O2)2C6H4NO2] 2 H2O;bpV(pic) (potassium hydrate) | | CAS: | 148556-27-8 | | MF: | C6H8K2NO9V-3 | | MW: | 367.26712 | | EINECS: | | Product Categories: | | Mol File: | 148556-27-8.mol |
| BPV(PIC) Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble20mg/mL, clear | | form | powder | | color | faint yellow to dark yellow |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| BPV(PIC) Usage And Synthesis |
| Uses | bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM). bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. | | Uses | bpV(pic) is a potent protein PTP inhibitor. | | Biochem/physiol Actions | bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK). |
| BPV(PIC) Preparation Products And Raw materials |
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