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| AACOCF3 Basic information |
| Product Name: | AACOCF3 | | Synonyms: | 1,1,1-TRIFLUOROMETHYL-6,9,12,15-HEIEICOSATETRAEN-2-ONE;1,1,1-TRIFLUORO-6,9,12,15-HENEICOSATETRAEN-2-ONE;1,1,1-TRIFLUORO-6Z,9Z,12Z,15Z-HENEICOSATERAEN-2-ONE;1,1,1-TRIFLUORO-6Z,9Z-12Z,15Z-HENEICOSATETRAEN-2-ONE;AATFMK;AACOCF3;ARACHIDONYL TRIFLUOROMETHYL KETONE INHIB ITS ANANDAMIDE H;1,1,1-Trifluoromethyl-6,9,12,15-heieicosatetraen-2-one, AACOCF3, Arach-CF3 | | CAS: | 149301-79-1 | | MF: | C21H31F3O | | MW: | 356.47 | | EINECS: | | Product Categories: | Lipid signaling | | Mol File: | 149301-79-1.mol |
| AACOCF3 Chemical Properties |
| Boiling point | 421.7±45.0 °C(Predicted) | | density | 0.981±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: >5 mg/mL | | form | liquid | | color | yellow | | Stability: | Light Sensitive |
| AACOCF3 Usage And Synthesis |
| Uses | Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures. | | Definition | ChEBI: A fatty acid derivative that is arachidonic acid in which the OH part of the carboxy group has been replaced by a trifluoromethyl group | | Biological Activity | Inhibitor of cytosolic (85 kDa) phospholipase A 2 . Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro . | | Biochem/physiol Actions | Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets. | | references | [1]. ackermann ej, conde-frieboes k, dennis ea. inhibition of macrophage ca(2+)-independent phospholipase a2 by bromoenol lactone and trifluoromethyl ketones. j biol chem, 1995, 270(1): 445-450.[2]. riendeau d, guay j, weech pk, et al. arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kda phospholipase a2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. j biol chem, 1994, 269(22): 15619-15624.[3]. malaviya r, ansell j, hall l, et al. targeting cytosolic phospholipase a2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice. eur j pharmacol, 2006, 539(3): 195-204. |
| AACOCF3 Preparation Products And Raw materials |
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