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| N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Basic information |
| Product Name: | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride | | Synonyms: | N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaminehydrochloride;NE 100 hydrochloride;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaMine;N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride;NE-100;NE100;NE 100;NE100 HCl | | CAS: | 149409-57-4 | | MF: | C23H33NO2.HCl | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | 149409-57-4.mol |
| N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Chemical Properties |
| Melting point | 94-96°C | | storage temp. | 2-8°C | | solubility | H2O: soluble15mg/mL, clear | | form | powder | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Usage And Synthesis |
| Description | NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50?= 1.5 nM) over sigma-2 (IC50?= 85 nM).1,2?NE-100 suppressed ischemia-induced neuronal cell death in mice?via?upregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.3 | | Uses | NE-100 is a potent and selective σ1 receptor antagonist. | | Biological Activity | Potent and selective σ 1 receptor antagonist (K i = 0.86 nM) that displays > 55-fold selectivity over σ 2 receptors and > 6000-fold selectivity over D 1 , D 2 , 5-HT 1A , 5-HT 2 and PCP receptors. Exhibits reversible binding (K d = 1.2 nM) and displays antipsychotic activity in vivo . Orally active. | | Biochem/physiol Actions | NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. | | References | 1) Okuyama?et al.?(1994),?NE-100, a novel sigma receptor ligand: in vivo tests; Life Sci.?53?PL285
2) Chaki?et al.?(1994),?NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain; Eur. J. Pharmacol.?251?R1
3) Ono?et al.?(2013),?A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells; Biochem. Biophys. Res. Commun.?434?904 |
| N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Preparation Products And Raw materials |
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