| 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT Basic information |
| Product Name: | 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT |
| Synonyms: | 4-METHYL-7-(SULFOOXY)-2H-1-BENZOPYRAN-2-ONE POTASSIUM SALT;4-METHYLUMBELLIFERONE SULFATE POTASSIUM SALT;4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT;4-METHYLUMBELLIFERYL SULPHATE POTASSIUM SALT;4-MUS;4-MU-SULFATE K;7-HYDROXY-4-METHYLCOUMARIN SULFATE POTASSIUM SALT;potassium (4-methyl-2-oxo-2H-1-benzopyran-7-yl)sulphate |
| CAS: | 15220-11-8 |
| MF: | C10H7KO6S |
| MW: | 294.32 |
| EINECS: | 239-272-2 |
| Product Categories: | substrate;Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;Labeling and Diagnostics Reagents;Aromatics;Heterocycles;Sulfur & Selenium Compounds |
| Mol File: | 15220-11-8.mol |
| 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT Chemical Properties |
| Melting point | 287-290°C |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Powder |
| color | White to Pale Yellow |
| Water Solubility | Soluble in water at 5mg/ml |
| BRN | 3803203 |
| Stability: | Stable in unbuffered solution for several months at -20° |
| CAS DataBase Reference | 15220-11-8(CAS DataBase Reference) |
| EPA Substance Registry System | 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (15220-11-8) |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT Usage And Synthesis |
| Chemical Properties | Crystalline Solid |
| Uses | Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells that is an artifact generated by trichloroacetic acid extraction. MUS is used as a fluorimetric substrate for arylsulphatase enzyme. Subsitution of the hydroxyl group of 4-Methylumbelliferyl sulfate potassium salt causes the excitation wavelength of the umbelliferone to shift to shorter values and also brings about a decrease in fluorescence. Fluorescence: max. Abs = 334 mm; max. Em. = 370 mm |
| Uses | 4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors. |
| 4-METHYLUMBELLIFERYL SULFATE POTASSIUM SALT Preparation Products And Raw materials |
| Raw materials | Ethanol-->Sulfuric acid-->Ethyl acetoacetate-->Resorcinol-->Pyridine sulfur trioxide |
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