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| BMY 45778 Basic information |
| Product Name: | BMY 45778 | | Synonyms: | [3-(4,5-DIPHENYL[2,4'-BIOXAZOL]-5'-YL)PHENOXY]ACETIC ACID;BMY 45778;Acetic acid, 2-[3-(4,5-diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]-;BMY 45778 >=98% (HPLC) | | CAS: | 152575-66-1 | | MF: | C26H18N2O5 | | MW: | 438.43 | | EINECS: | | Product Categories: | | Mol File: | 152575-66-1.mol |
| BMY 45778 Chemical Properties |
| Boiling point | 659.9±65.0 °C(Predicted) | | density | 1.298±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | ≥67.6 mg/mL in DMSO | | form | powder | | pka | 3.10±0.10(Predicted) | | color | white to beige |
| BMY 45778 Usage And Synthesis |
| Uses | BMY 45778 is an agonist for IP receptor to up-regulate the expression of C?/EBPβ and C?/EBPδ. | | Biological Activity | Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP 1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC 50 = 27-35 nM). | | Biochem/physiol Actions | BMY 45778 is a non-prostanoid prostacyclin agonist. | | references | [1]. seiler sm, brassard cl, federici me, et al. [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (bmy 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, camp levels, protein kinase, and iloprost binding. prostaglandins, 1997, 53(1): 21-35.[2]. wise h, qian ym, jones rl. a study of prostacyclin mimetics distinguishes neuronal from neutrophil ip receptors. eur j pharmacol, 1995, 278(3): 265-269. |
| BMY 45778 Preparation Products And Raw materials |
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