Other grades of this product :
| NS 1619 Basic information |
| Product Name: | NS 1619 | | Synonyms: | NS 1619;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE;1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;NS1619;NS 1619;NS 161;2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)- | | CAS: | 153587-01-0 | | MF: | C15H8F6N2O2 | | MW: | 362.23 | | EINECS: | | Product Categories: | API | | Mol File: | 153587-01-0.mol |
| NS 1619 Chemical Properties |
| density | 1.563±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL | | pka | 8.32±0.48(Predicted) | | form | solid | | color | white |
| NS 1619 Usage And Synthesis |
| Uses | NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart. | | Definition | ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i
an opener/activator of the large-conductance calcium-activated potassium channel (Bkca). | | Biochem/physiol Actions | NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury. |
| NS 1619 Preparation Products And Raw materials |
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