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| CLASTO-LACTACYSTIN BETA-LACTONE Basic information |
| CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties |
| Melting point | 186-187°C | | storage temp. | -20°C | | solubility | DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine | | form | White solid | | color | White |
| CLASTO-LACTACYSTIN BETA-LACTONE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin. | | Uses | Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor. | | Uses | clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor. | | Biological Activity | cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin | | Biochem/physiol Actions | Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits. |
| CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials |
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