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| 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Basic information |
| Product Name: | 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate | | Synonyms: | NSC 109555;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2);NSC109555 Dimesylate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;NSC 109555 ditosylate;DDUG dimethanesulfonate;DDUG diMS | | CAS: | 15427-93-7 | | MF: | C20H28N10O4S | | MW: | 504.56592 | | EINECS: | | Product Categories: | | Mol File: | 15427-93-7.mol |
| 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige |
| 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Usage And Synthesis |
| Uses | NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be b
eneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caus
ed acute paralysis leading to apnea and death. | | Uses | NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death. | | Biochem/physiol Actions | NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM. |
| 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Preparation Products And Raw materials |
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