Product

(S)-(-)-2-Methyl-1-butanol

CAS No.：1565-80-6

Other grades of this product :

(S)-(-)-2-Methyl-1-butanol Basic information

Product Name:	(S)-(-)-2-Methyl-1-butanol
Synonyms:	(S)-2-Methyl-1-butanol,99%e.e.;(S)-(-)-2-Methylbutanol >=95.0% (suM of enantioMers, GC);(S)-(-)-2-Methylbutanol 99%;(s)-1-butano;(S)-2-methyl-butan-1-ol;AMYL ALCOHOL, N-;AMYL ALCOHOL;AMYL ALCOHOL, NORMAL
CAS:	1565-80-6
MF:	C5H12O
MW:	88.15
EINECS:	216-366-1
Product Categories:	Building Blocks for Liquid Crystals;Chiral Building Blocks;Chiral Compounds (Building Blocks for Liquid Crystals);Functional Materials;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry
Mol File:	1565-80-6.mol

(S)-(-)-2-Methyl-1-butanol Chemical Properties

Melting point	-70 °C
alpha	-5.8 º (neat 23 ºC)
Boiling point	136-138 °C(lit.)
density	0.811 g/mL at 25 °C(lit.)
vapor density	3 (vs air)
vapor pressure	1 mm Hg ( 13.6 °C)
refractive index	n20/D 1.409(lit.)
Fp	120 °F
storage temp.	2-8°C
pka	15.24±0.10(Predicted)
form	clear liquid
color	Colorless to Almost colorless
optical activity	[α]23/D 5.8°, neat
Water Solubility	36 g/L (30 ºC)
Merck	14,6030
BRN	1718809
CAS DataBase Reference	1565-80-6(CAS DataBase Reference)
NIST Chemistry Reference	1-Butanol, 2-methyl-, (S)-(1565-80-6)
EPA Substance Registry System	1-Butanol, 2-methyl-, (2S)- (1565-80-6)

Safety Information

Hazard Codes	Xn
Risk Statements	10-20-37-66-2017/10/20
Safety Statements	46-24/25
RIDADR	UN 1105 3/PG 3
WGK Germany	1
RTECS	SB9800000
HazardClass	3
PackingGroup	III
HS Code	29051990

MSDS Information

Provider	Language
(S)-(-)-sec-Butylcarbinol	English
SigmaAldrich	English
ACROS	English
ALFA	English

(S)-(-)-2-Methyl-1-butanol Usage And Synthesis

Chemical Properties	clear colourless liquid
Uses	(S)-(-)-2-Methylbutanol can be used as a reactant to prepare: Methylbutyl-2-(3-thienyl)acetate (MBTA) by esterification reaction with 3-thiophene acetic acid in the presence of an acid catalyst. (2S)-2-Methyl-1-butanesulfenyl chloride by reacting with thioacetic acid using Mitsunobu reaction conditions. (+)-Violapyrone C and (-)-myxalamide A.
Uses	(S)-(?)-2-Methylbutanol can be used to prepare: (S)-(?)-2-Methyl-1-butyloxy carbonyl amino hexyl isocyanate (MBI), which is used to synthesize isocyanate copolymers. Chiral alkoxynaphathoic acid derivatives having liquid crystalline properties. 3,4-Bis[(S)-2-methylbutoxy]thiophene, a key intermediate for the synthesis of polythiophenes.
Definition	ChEBI: The (S)-enantiomer of 2-methylbutan-1-ol.
General Description	rest mainly 3-methyl-1-butanol
Purification Methods	Reflux the butanol with CaO, distil, reflux with magnesium and again fractionally distil it. A small sample of highly purified material is obtained by fractional crystallisation after conversion into a suitable ester such as the trinitrophthalate or the 3-nitrophthalate. The latter is converted to the cinchonine salt in acetone and recrystallised from CHCl3 by adding pentane. The salt is saponified, extracted with ether, and fractionally distilled. [Terry et al. J Chem Eng Data 5 403 1960, Beilstein 1 IV 1666.]

(S)-(-)-2-Methyl-1-butanol Preparation Products And Raw materials

Raw materials	Ethyl acetate-->Tetrahydrofuran-->Lithium Aluminum Hydride-->Sodium borohydride-->(S)-(+)-2-Methylbutyric acid
Preparation Products	S-2-Methylbutanal-->2-methylbutyl butyrate-->(R)-2-Methylbutanol

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