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| 5-Nonyloxytryptamine oxalate Basic information |
| 5-Nonyloxytryptamine oxalate Chemical Properties |
| storage temp. | room temp | | solubility | DMSO: soluble2mg/mL, clear (warmed) | | form | powder | | color | , white to yellow to light brown |
| 5-Nonyloxytryptamine oxalate Usage And Synthesis |
| Description | Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor. It is selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity, with an EC50 greater than 1 μM for 5-HT1A. It binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization. | | Uses | 5-Nonyloxytryptamine Oxalate is a selective 5-HT1B agonist. | | Biochem/physiol Actions | Nonyloxytryptamine (5-nonyloxytryptamine) is a potent and selective 5-HT1B receptor agonist. Nonyloxytryptamine is a polysialic acid (PSA) mimick that triggers PSA-mediated functions. Nonyloxytryptamine enhances neurite outgrowth of cultured primary neurons, protects neurons from oxidative stress, enhanced Schwann cell proliferation, reduces migration of astrocytes and enhances myelination in vitro. |
| 5-Nonyloxytryptamine oxalate Preparation Products And Raw materials |
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