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| Ethyl (hydroxyimino)cyanoacetate potassium salt Basic information |
| Product Name: | Ethyl (hydroxyimino)cyanoacetate potassium salt | | Synonyms: | 2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt;Ethyl (hydroxyimino)cyanoacetate potassium salt;K-Oxyma;Cyano(hydroxyimino)acetic acid ethyl ester potassium salt;2-Cyano-2-(hydroxyimino)acetic acid ethyl ester potassium salt (1:1);Ethyl (hydroxyimino)cyanoacetate potassium;K-Oxyma≥ 99% (HPLC);K-Oxyma Pure Novabiochem | | CAS: | 158014-03-0 | | MF: | C5H5KN2O3 | | MW: | 180.2031 | | EINECS: | | Product Categories: | | Mol File: | 158014-03-0.mol |
| Ethyl (hydroxyimino)cyanoacetate potassium salt Chemical Properties |
| Melting point | 145-155°C | | storage temp. | 2-8°C |
| Hazard Codes | T | | Risk Statements | 20/21-25-43 | | Safety Statements | 36/37-45 | | RIDADR | UN 3439 6.1 / PGIII | | WGK Germany | 3 | | HS Code | 2928 00 90 |
| Ethyl (hydroxyimino)cyanoacetate potassium salt Usage And Synthesis |
| Chemical Properties | Bright yellow powder | | Uses | Useful in peptide coupling on mild acid-labile resins with minimal to no cleavage of the peptide from the resin due to its more alkaline character. This can be used to replace the explosive HOBt and HOAt. | | Uses | - Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
- Outperforms HOAt in sterically demanding peptide bond formations
- Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
- Less epimerization than HOBt in fragment condensation reactions
- K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
- K-salt has a higher melting point than OxymaPure
| | Uses | Ethyl (hydroxyimino)cyanoacetate potassium salt is a Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure.
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| Ethyl (hydroxyimino)cyanoacetate potassium salt Preparation Products And Raw materials |
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