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| L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Basic information |
| Product Name: | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE | | Synonyms: | L-NIL DIHYDROCHLORIDE;L-NIL HCL;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE;L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2);L-Lysine ω-acetamidine dihydrochloride | | CAS: | 159190-45-1 | | MF: | C8H19Cl2N3O2 | | MW: | 260.16 | | EINECS: | | Product Categories: | Nitric Oxide | | Mol File: | 159190-45-1.mol |
| L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemical Properties |
| storage temp. | -20°C | | form | White to off-white solid. |
| Provider | Language |
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ACROS
| English |
| L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Usage And Synthesis |
| Description | L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major. | | Uses | L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor: - to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
| | Biochem/physiol Actions | Selective inhibitor of inducible nitric oxide synthase (iNOS). |
| L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Preparation Products And Raw materials |
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