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| BW 723C86 Basic information |
| Product Name: | BW 723C86 | | Synonyms: | BW 723C86;BW 723C86 HYDROCHLORIDE;ALPHA-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-ETHANAMINE HYDROCHLORIDE;ALPHA-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-ETHANAMINE, MONOHYDROCHLORIDE;BW 723C86 \ 5-HT2B SEROTONIN RECEPTOR AG ONIST;a-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanaminehydrochloride;BW723C86HCl;a-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine Monohydrochloride | | CAS: | 160521-72-2 | | MF: | C16H19ClN2OS | | MW: | 322.85 | | EINECS: | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor | | Mol File: | 160521-72-2.mol |
| BW 723C86 Chemical Properties |
| storage temp. | Desiccate at +4°C | | solubility | DMSO: >10 mg/mL | | form | solid | | color | white |
| WGK Germany | 3 | | RTECS | NL8504715 |
| BW 723C86 Usage And Synthesis |
| Uses | BW 723C86 is a selective 5-HT2B receptor agonist. It is used in the treatment of certain CNS disorders, in particular epilepsy, migraine and feeding disorders.
| | Biological Activity | Selective 5-HT 2B receptor agonist. | | Biochem/physiol Actions | 5-HT2B serotonin receptor agonist. | | references | [1]. kennett ga, bright f, trail b, et al. effects of the 5-ht2b receptor agonist, bw 723c86, on three rat models of anxiety. br j pharmacol, 1996, 117(7): 1443-1448.[2]. dergacheva o, wang x, kamendi h, et al. 5ht2 receptor activation facilitates p2x receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. neuropharmacology, 2008, 54(7): 1095-1102. [3]. kennett ga, trail b, bright f. anxiolytic-like actions of bw 723c86 in the rat vogel conflict test are 5-ht2b receptor mediated. neuropharmacology, 1998, 37(12): 1603-1610.[4]. urtikova n, berson n, van steenwinckel j, et al. antinociceptive effect of peripheral serotonin 5-ht2b receptor activation on neuropathic pain. pain, 2012, 153(6): 1320-1331. |
| BW 723C86 Preparation Products And Raw materials |
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