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| BENZAMIL HYDROCHLORIDE Basic information |
| Product Name: | BENZAMIL HYDROCHLORIDE | | Synonyms: | Benzamil hydrate hydrochloride;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrate hydrochloride;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate;Benzamil hydrochloride hydrate;3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide,hydrochloride;3;5-DIAMINO-6-CHLORO-N-[IMINO[(PHENYLMETHYL)AMINO]METHYL]-2-PYRAZINECARBOXAMIDE; MONOHYDROCHLORIDE;5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride | | CAS: | 161804-20-2 | | MF: | C13H14ClN7OHCl | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | 161804-20-2.mol |
| BENZAMIL HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | methanol: soluble10mg/mL | | form | solid | | color | yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or may be stored at -20°C for up to 3 months. |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| BENZAMIL HYDROCHLORIDE Usage And Synthesis |
| Description | Benzamil (161804-21-2) is a more potent (Ki = 10 nM vs 182 nM1, IC50 = 9 μM2) version of the epithelial sodium channel blocker Amiloride. It is also an inhibitor of Na+/Ca2+ exchange transport (IC50 = 11 μM)2 and the Na+/H+ antiporter (IC50 = 80 nM)2. | | Biochem/physiol Actions | Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels | | References | Cuthbert and Fanelli (1978), Effects of some pyrazinecarboxamides on sodium transport in frog skin; J. Pharmacol. 63 139
Kleyman and Cragoe (1988), Amiloride and Its Analogs as Tools in the Study of Ion Transport; Membrane Biol. 105 1 |
| BENZAMIL HYDROCHLORIDE Preparation Products And Raw materials |
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