5-METHOXYGRAMINE

CAS No.：16620-52-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-METHOXYGRAMINE Basic information

Product Name:	5-METHOXYGRAMINE
Synonyms:	5-METHOXYGRAMINE 99%;5-Methoxygramine, N,N-Dimethyl-(5-methoxy-1H-indol-3-yl)methylamine;methoxygramine;5-Methoxygramine or 5-Methoxy-3-(Dimethylaminomethyl)-indole;(5-methoxy-1H-indol-3-yl)methyl-dimethylammonium;3-ETHYL-1H-PYRAZOL-5-AMINE HCL;5-Methoxygramine,99%;NSC 88885
CAS:	16620-52-3
MF:	C12H16N2O
MW:	204.27
EINECS:	240-669-8
Product Categories:	Building Blocks;C12;Indoline & Oxindole;Chemical Synthesis;Heterocyclic Building Blocks;Indoles;Indoles and derivatives;Heterocyclic Compounds
Mol File:	16620-52-3.mol

5-METHOXYGRAMINE Chemical Properties

Melting point	123-126 °C (lit.)
Boiling point	342.77°C (rough estimate)
density	1.0565 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Refrigerator (+4°C)
pka	16.70±0.30(Predicted)
BRN	170533
CAS DataBase Reference	16620-52-3(CAS DataBase Reference)

Safety Information

Hazard Codes	C,Xi
Risk Statements	34-22
Safety Statements	22-24/25
WGK Germany	3
RTECS	NL7700000
F	10
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

5-METHOXYGRAMINE Usage And Synthesis

Chemical Properties	white to almost white crystalline powder
Uses	• ;Reactant for preparation of dopamine D2 receptor antagonists1• ;Reactant for asymmetric preparation of ethenyl(tetrahydro)carbazoledicarboxylates via gold(I)-catalyzed intramolecular Friedel-Crafts allylic alkylation reaction2• ;Reactant for preparation of N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ols as dopamine D2-like receptor ligands3• ;Reactant for preparation of substituted N-trimethoxybenzoyl indoles, indolines, and a tetrahydroquinoline via N-aroylation with trimethoxybenzoyl chloride or anhydride as antitubulin agents4• ;Reactant for preparation of in
Uses	Reactant for preparation of dopamine D2 receptor antagonists Reactant for asymmetric preparation of ethenyl(tetrahydro)carbazoledicarboxylates via gold(I)-catalyzed intramolecular Friedel-Crafts allylic alkylation reaction Reactant for preparation of N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ols as dopamine D2-like receptor ligands Reactant for preparation of substituted N-trimethoxybenzoyl indoles, indolines, and a tetrahydroquinoline via N-aroylation with trimethoxybenzoyl chloride or anhydride as antitubulin agents Reactant for preparation of indolylmethanesulfonamide and its methoxy derivatives

5-METHOXYGRAMINE Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Diethyl ether-->Acetic acid-->Formaldehyde-->Dimethylamine-->5-Methoxyindole

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