Other grades of this product :
| Product Name: | DS-437 | | Synonyms: | DS-437;DS-437
(DS437;Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-;DS-437 >=98% (HPLC) | | CAS: | 1674364-87-4 | | MF: | C15H23N7O4S | | MW: | 397.45 | | EINECS: | | Product Categories: | | Mol File: | 1674364-87-4.mol |
| DS-437 Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white to beige |
| RIDADR | UN 2811 6.1 / PGIII |
| DS-437 Usage And Synthesis |
| Description | DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC50s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185erbB2/neu antibody 4D5. | | Uses | DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells. | | Biochem/physiol Actions | DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases. |
| DS-437 Preparation Products And Raw materials |
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