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| 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Basic information |
| Product Name: | 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT | | Synonyms: | 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT;disufenton sodium;Cerovive;D03875;Disufenton sodium (usan/inn);NXY-059(Disufentonsodium);Disufenton sodium (NXY-059);4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonicaciddisodiumsalt | | CAS: | 168021-79-2 | | MF: | C11H14NNa2O7S2 | | MW: | 382.3409 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 168021-79-2.mol |
| 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Chemical Properties |
| Melting point | >300 °C | | storage temp. | -20°C | | solubility | Soluble in DMSO | | form | powder | | color | white to beige |
| 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Usage And Synthesis |
| Uses | Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Neuroprotectant. | | Uses | A free radical trapping compound | | Uses | Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Used as a spin-trap agent. It is a clinically tested antioxidant and depicts potency against Ischemic stress, Neuroprotection. | | Biological Activity | Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant. | | Biochem/physiol Actions | Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water). | | references | [1] kuroda s1, tsuchidate r, smith ml, maples kr, siesjö bk. |
| 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Preparation Products And Raw materials |
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![1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT](/img/168021-79-2.jpg "1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT")
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