Other grades of this product :
| Product Name: | OSMI-1 | | Synonyms: | OSMI-1;Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-;OSMI-1 >=98% (HPLC);(R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide | | CAS: | 1681056-61-0 | | MF: | C28H25N3O6S2 | | MW: | 563.64 | | EINECS: | | Product Categories: | API | | Mol File: | 1681056-61-0.mol |
| OSMI-1 Chemical Properties |
| density | 1.389±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | powder | | pka | 8.77±0.20(Predicted) | | color | white to beige |
| OSMI-1 Usage And Synthesis |
| Uses | OSMI 1 is a novel inhibitor of O-GlcNAc transferase (OGT). | | Uses | OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase. | | Biochem/physiol Actions | OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease. |
| OSMI-1 Preparation Products And Raw materials |
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