Other grades of this product :
| FTI-277 Basic information |
| Product Name: | FTI-277 | | Synonyms: | METHYL[N-[2-PHENYL-4-N-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO] BENZOYL]]-METHIONATE, TFA;FTI-277;N-[4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL]METHIONINE METHYL ESTER TRIFLUOROACETATE SALT;N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt;N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-methionine methyl ester;FTI-277;FTI277;L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester | | CAS: | 170006-73-2 | | MF: | C22H29N3O3S2 | | MW: | 447.61 | | EINECS: | | Product Categories: | | Mol File: | 170006-73-2.mol |
| FTI-277 Chemical Properties |
| Boiling point | 684.2±55.0 °C(Predicted) | | density | 1.222±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: soluble | | form | amorphous semi-solid | | pka | 9.81±0.10(Predicted) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| FTI-277 Usage And Synthesis |
| Uses | Farnesyltransferase inhibitor 277 (FTI-277) has been used to:- inhibit protein farnesylation in breast cell lines.
- in marrow-isolated adult multilineage inducible cells (MIAMI).
- inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).
| | Biochem/physiol Actions | Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent. |
| FTI-277 Preparation Products And Raw materials |
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