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| SQ 22,536 Basic information |
| Product Name: | SQ 22,536 | | Synonyms: | 9-(2-tetrahydrofuryl)adenine;SQ 22,536 ADENYLATE CYCLASE INH;9-(Tetrahydro-2-furynal)-9H-purin-6-amine;SQ22,536/Inhibitor;9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade;6-Amino-9-[(tetrahydrofuran)-2-yl]-9H-purine;9-(Tetrahydrofuran-2-yl)-9H-purine-6-amine;6-Amino-9-(tetrahydro-2-furyl)-9H-purine | | CAS: | 17318-31-9 | | MF: | C9H11N5O | | MW: | 205.22 | | EINECS: | 633-987-7 | | Product Categories: | | Mol File: | 17318-31-9.mol |
| SQ 22,536 Chemical Properties |
| Melting point | 160-161℃ | | Boiling point | 474.8±55.0 °C(Predicted) | | density | 1.70±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | H2O: 21 mg/mL | | form | solid | | pka | 3.82±0.10(Predicted) | | color | white to off-white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| SQ 22,536 Usage And Synthesis |
| Description | SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation. | | Uses | SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells. | | Definition | ChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor. | | Biological Activity | Inhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets. | | Biochem/physiol Actions | SQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.1 It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.2 |
| SQ 22,536 Preparation Products And Raw materials |
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