Other grades of this product :
| methyl 3-(4-methylphenylsulfonamido)benzoate Basic information |
| methyl 3-(4-methylphenylsulfonamido)benzoate Chemical Properties |
| Melting point | 152-154 °C | | Boiling point | 456.5±55.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly) | | form | powder | | pka | 7.88±0.10(Predicted) | | color | off-white to purple |
| methyl 3-(4-methylphenylsulfonamido)benzoate Usage And Synthesis |
| Biochem/physiol Actions | A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth. |
| methyl 3-(4-methylphenylsulfonamido)benzoate Preparation Products And Raw materials |
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