Product

1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

CAS No.：17364-16-8

Other grades of this product :

1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Basic information

Product Name:	1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyms:	P-LYSO-PC;L-ALPHA-PALMITOYL-LYSOPHOSPHATIDYLCHOLINE;L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, PALMITOYL;L-GAMMA-PALMITOYL-ALPHA-LYSOLECITHIN;LYSOLECITHIN, PALMITOYL;LYSO-PPC;LYSO-PC;3-SN-LYSOPHOSPHATIDYLCHOLINE, 1-PALMITOYL
CAS:	17364-16-8
MF:	C24H50NO7P
MW:	495.64
EINECS:
Product Categories:	Fatty Acid Derivatives & Lipids;Glycerols
Mol File:	17364-16-8.mol

1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties

Melting point	253 °C
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Solid
color	White to Off-White
BRN	5385682

Safety Information

WGK Germany	3
F	10-21

MSDS Information

Provider	Language
SigmaAldrich	English

1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Usage And Synthesis

Description	1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A₂ (PLA₂) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 μM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 μM. It increases TGF-β1 production and enhances Foxp3 protein levels in T_reg cells in isolated human peripheral blood when used at a concentration of 10 μM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.
Chemical Properties	White Solid
Uses	A lipid biomarker for stable and unstable heart disease.
Uses	16:0 Lyso PC has been used to reveal the central role of the adipocyte inflammasome in homocysteine-induced insulin resistance. It has also been used for lipid extraction and mass spectrometry analysis.
Biochem/physiol Actions	1-Palmitoyl-sn-glycero-3-phosphocholine may be used as a substrate to identify, differentiate and characterize lysophosphocholine acyl transferases.

1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials

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