Other grades of this product :
| (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Basic information |
| Product Name: | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride | | Synonyms: | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF04859989 hydrochloride;PF-04859989 hydrochloride;PF-4859989 hydrochloride;PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF-04859989 hydrochloride >=98% (HPLC) | | CAS: | 177943-33-8 | | MF: | C9H11ClN2O2 | | MW: | 214.64884 | | EINECS: | | Product Categories: | | Mol File: | 177943-33-8.mol |
| (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Chemical Properties |
| storage temp. | room temp | | solubility | H2O: soluble20mg/mL, clear | | form | powder | | color | white to beige |
| (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Usage And Synthesis |
| Biochem/physiol Actions | PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates. |
| (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Preparation Products And Raw materials |
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