Product

(2R,3S)-N-Benzoyl-3-phenyl Isoserine

CAS No.：132201-33-3

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(2R,3S)-N-Benzoyl-3-phenyl Isoserine Basic information

Product Name:	(2R,3S)-N-Benzoyl-3-phenyl Isoserine
Synonyms:	N-BENZOYL-(2R,3S)-3-AMINO-2-HYDROXY-3-PHENYL-PROPIONIC ACID;N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE;TAXOL(R) SIDE CHAIN;(2R,3S)-3-Benzoylamino-2-Hydro;(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionacid;Taxol side chain alcohol;(2R, 3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONACID,98+%;(2R,3S)-3-Benzoylamino-2-hydroxy-3-phenylpropionic acid
CAS:	132201-33-3
MF:	C16H15NO4
MW:	285.3
EINECS:	631-348-7
Product Categories:	Herb extract;Serine Derivatives;Peptide Synthesis;Unnatural Amino Acid Derivatives;Amino Acids & Derivatives;Anti-virals;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	132201-33-3.mol

(2R,3S)-N-Benzoyl-3-phenyl Isoserine Chemical Properties

Melting point	169-172 °C (lit.)
Boiling point	580.7±50.0 °C(Predicted)
density	1.316±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Acetonitrile (Slightly), DMSO (Slightly), Ethanol (Slightly)
form	Solid
pka	3.40±0.17(Predicted)
color	White to Off-White
optical activity	[α]20/D 40°, c = 1.0 in ethanol
CAS DataBase Reference	132201-33-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29242990

MSDS Information

Provider	Language
SigmaAldrich	English

(2R,3S)-N-Benzoyl-3-phenyl Isoserine Usage And Synthesis

Uses	(2R,3S)-N-Benzoyl-3-phenylisoserine is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites. (2R,3S)-N-Benzoyl-3-phenylisoserine shows cytotoxic, antiviral and immunomodulatory activity.
Uses	The presence of this chiral side chain has proven to be essential for the biological activity of taxol, one of the most promising anticancer agents being investigated. The challenging synthesis of taxol has stimulated interest in the attachment of the C-13 side chain to naturally derived taxanes like baccatin III.

(2R,3S)-N-Benzoyl-3-phenyl Isoserine Preparation Products And Raw materials

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